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CAY10506

CAT: 0804-HY-118988Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118988Size:1 Each
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Description
CAY10506 is a PPARγ ligand that can induce cell death and ROS production in a PPARγ-dependent manner in vitro. CAY10506 exhibits radiosensitizing effects, enhancing γ-radiations-induced apoptosis and caspase-3-mediated poly (ADP-ribose) polymerase (PARP) cleavage. CAY10506 can be used in cancer research[1].
CAS Number
292615-75-9
UNSPSC
12352005
Hazard Statement
H225-H302-H319-H336
Target
Apoptosis; PPAR
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cay10506.html
Solubility
10 mM in DMSO
Smiles
O=C1SC(CC2=CC=C(C=C2)OCCNC(CCCCC3SSCC3)=O)C(N1)=O
Molecular Formula
C20H26N2O4S3
Molecular Weight
454.63
Precautions
P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P330-P370+P378-P403+P233-P403+P235-P405-P501
References & Citations
[1]Han EJ, et al. Combined treatment with peroxisome proliferator-activated receptor (PPAR) gamma ligands and gamma radiation induces apoptosis by PPARγ-independent up-regulation of reactive oxygen species-induced deoxyribonucleic acid damage signals in non-small cell lung cancer cells. Int J Radiat Oncol Biol Phys. 2013 Apr 1;85 (5) :e239-48.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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