DBCO-NHS ester

• UNSPSC Description:

  DBCO-NHS ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• Target Antigen:

  ADC Linker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dbco-nhs-ester.html

• Purity:

  99.53

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(CCC(ON(C(CC1)=O)C1=O)=O)N(C(C=CC=C2)=C2C#C3)CC4=C3C=CC=C4

• Molecular Weight:

  402.40

• References & Citations:

  [1]Method for identifying potential drug target protein useful for development of antibody drug, and method for producing antibody directed against target protein. WO2018151301A1.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1353016-71-3