DOTA-​NHS-ester

• Description :

  DOTA-NHS-ester is a linker for affibody molecules and is applied in small animals PET, SPECT, and CT. DOTA-NHS-ester can be used to label radiotherapeutic agents or imaging probes for the detection of tumors[1].

• UNSPSC :

  12352203

• Hazard Statement :

  H315, H319

• Target :

  ADC Linker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dota-nhs-ester.html

• Purity :

  97.0

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(ON1C(CCC1=O)=O)CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2

• Molecular Formula :

  C20H31N5O10

• Molecular Weight :

  501.49

• Precautions :

  H315, H319

• References & Citations :

  [1]Hoppmann S, et al. Radiolabeled affibody-albumin bioconjugates for HER2-positive cancer targeting.Bioconjug Chem. 2011 Mar 16;22 (3) :413-2

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• CAS Number :

  [170908-81-3]