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Pyridostatin (TFA)

CAT: 0804-HY-15176B-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15176B-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pyridostatin (RR82) TFA is a G-quadruplex DNA stabilizing agent (Kd=490 nM) and can target DNA and RNA G4s in cells. Pyridostatin TFA promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin TFA targets the proto-oncogene Src. Pyridostatin TFA reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells[1][2][3].
CAS Number
1472611-44-1
Product Name Alternative
RR82 (TFA)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
G-quadruplex
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pyridostatin-tfa.html
Purity
99.54
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NC(C(NC2=NC3=CC=CC=C3C(OCCN)=C2)=O)=CC(OCCN)=C1)NC4=NC5=CC=CC=C5C(OCCN)=C4.O=C(O)C(F)(F)F
Molecular Formula
C33H33F3N8O7
Molecular Weight
710.66
Precautions
H302, H315, H319, H335
References & Citations
[1]Rodriguez R, et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012;8 (3) :301-310. Published 2012 Feb 5.|[2]Koirala D, et al. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem. 2011;3 (10) :782-787. Published 2011 Aug 28.|[3]Moruno-Manchon JF, et al. The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Aging (Albany NY) . 2017;9 (9) :1957-1970.|[4]Zhang X, et al. Chemical profiling of DNA G-quadruplex-interacting proteins in live cells. Nat Chem. 2021 Jul;13 (7) :626-633.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Nat Chem Biol. 2025 Aug 7.|ACS Omega. 2023 Sep 25;8 (40) :37369-37373.|Anal Chem. 2025 Jun 10;97 (22) :11617-11626.|Biochem Mol Biol Educ. 2020 Jul;48 (4) :329-336.|Int J Biol Macromol. 2021 Nov 1:190:178-188.|Int J Biol Macromol. 2025 Jun 20;319 (Pt 1) :145405.|iScience. 2022 Oct 9;25 (11) :105312.|J Med Virol. 2023 Jan;95 (1) :e28299.|J Natl Cancer Inst. 2023 Nov 8;115 (11) :1383-1391.|Nucleic Acids Res. 2019 Aug 22;47 (14) :7306-7320.|Nucleic Acids Res. 2022 Jun 24;50 (12) :6953-6967.|Nucleic Acids Res. 2024 Mar 21;52 (5) :2142-2156.|Biochemistry. 2024 Oct 15;63 (20) :2609-2620.|Biol Pharm Bull. 2019 May 1;42 (5) :721-727.|bioRxiv. 2025 March 14.|Cancer Res. 2025 Oct 1.|Emerg Microbes Infect. 2025 Jan 2:2447620.|Eur J Med Chem Rep. 2025 Dec.|Int J Biol Macromol. 2025 Jan 31:140556.|J Am Chem Soc. 2021 Dec 15;143 (49) :20779-20791.|J Ethnopharmacol. 2024 Apr 6:323:117694.|J Hepatol. 2020 Aug;73 (2) :371-382.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.|Med Chem Res. 2024 Nov 14.|Mol Cell. 2024 Jun 6;84 (11) :2070-2086.e20.|Nat Commun. 2022 Mar 17;13 (1) :1444.|Nat Commun. 2022 Sep 16;13 (1) :5456.|Nucleic Acids Res. 2023 Oct 27;51 (19) :10752-10767.|PLoS Pathog. 2023 Jan 26;19 (1) :e1011131.|Redox Biol. 2024 Sep:75:103247.

Chemical Information

Pyridostatin Trifluoroacetate
CAS Number1472611-44-1
PubChem CID117064504
IUPAC Name4-(2-aminoethoxy)-2-N,6-N-bis[4-(2-aminoethoxy)quinolin-2-yl]pyridine-2,6-dicarboxamide;2,2,2-trifluoroacetic acid
Molecular FormulaC33H33F3N8O7
Molecular Weight710.7
Topological Polar Surface Area240
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count16
Rotatable Bond Count13
Heavy Atom Count51
Formal Charge0
Complexity934
SMILES
C1=CC=C2C(=C1)C(=CC(=N2)NC(=O)C3=CC(=CC(=N3)C(=O)NC4=NC5=CC=CC=C5C(=C4)OCCN)OCCN)OCCN.C(=O)(C(F)(F)F)O
InChI
InChI=1S/C31H32N8O5.C2HF3O2/c32-9-12-42-19-15-24(30(40)38-28-17-26(43-13-10-33)20-5-1-3-7-22(20)36-28)35-25(16-19)31(41)39-29-18-27(44-14-11-34)21-6-2-4-8-23(21)37-29;3-2(4,5)1(6)7/h1-8,15-18H,9-14,32-34H2,(H,36,38,40)(H,37,39,41);(H,6,7)
InChIKey
SLFYRKZWSPFGQZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pyridostatin Trifluoroacetate
CAS: 1472611-44-1
CID: 117064504
Formula: C33H33F3N8O7
MW: 710.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight710.7
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count16
Rotatable Bond Count13
Exact Mass710.24242991
Monoisotopic Mass710.24242991
Topological Polar Surface Area240 Ų
Heavy Atom Count51
Formal Charge0
Complexity934
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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