Pyridostatin

• UNSPSC Description:

  Pyridostatin (RR82) is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets the proto-oncogene Src. Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells[1][2].

• Target Antigen:

  G-quadruplex

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Pyridostatin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC(OCCN)=CC(C(NC2=NC3=C(C(OCCN)=C2)C=CC=C3)=O)=N1)NC4=CC(OCCN)=C5C=CC=CC5=N4

• Molecular Weight:

  596.64

• References & Citations:

  [1]Rodriguez R, et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012;8(3):301-310. Published 2012 Feb 5.|[2]Koirala D, et al. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem. 2011;3(10):782-787. Published 2011 Aug 28.|[3]Moruno-Manchon JF, Koellhoffer EC, Gopakumar J, et al. The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Aging (Albany NY). 2017;9(9):1957-1970.ACS Omega. 2023 Sep 25.|Biochem Mol Biol Educ. 2020 Jul;48(4):329-336.|Int J Biol Macromol. 28 August 2021.|iScience. 9 October 2022, 105312.|J Med Virol. 2022 Nov 11.|J Natl Cancer Inst. 2023 Jul 22;djad142.|Nucleic Acids Res. 2019 Aug 22;47(14):7306-7320.|Nucleic Acids Res. 2022 Jun 24;50(12):6953-6967.|Nucleic Acids Res. 2024 Feb 10:gkae073.|Biochemistry. 2024 Sep 25.|J Am Chem Soc. 2021 Dec 6.|J Ethnopharmacol. 2023 Dec 30:117694.|J Hepatol. 2020 Aug;73(2):371-382.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Med Chem Res. 2024 Nov 14.|Mol Cell. 2024 Apr 26:S1097-2765(24)00285-5.|Nat Commun. 2022 Mar 17;13(1):1444.|Nat Commun. 2022 Sep 16;13(1):5456.|Nucleic Acids Res. 2023 Sep 22;gkad759.|PLoS Pathog. 2023 Jan 26;19(1):e1011131.|Redox Biol. 2024 Jun 19.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1085412-37-8