M40 (TFA)

• Description:

  M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas[1][2][3].

• UNSPSC:

  12352209

• Target:

  Neuropeptide Y Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/m40-tfa.html

• Purity:

  98.33

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(N2[C@@H](CCC2)C(N3[C@@H](CCC3)C(N4[C@@H](CCC4)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC(CNC([C@H](C)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@@H](NC(CN)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F.[x]

• Molecular Formula:

  C95H146N22O24.xC2HF3O2

• Molecular Weight:

  1980.31 (free base)

• References & Citations:

  [1]Narváez JA, et al., The galanin receptor antagonist M40 blocks the central cardiovascular actions of the galanin N-terminal fragment (1-15) . Eur J Pharmacol. 2000 Jul 7;399 (2-3) :197-203.|[2]McDonald MP, et al., Galanin inhibits performance on rodent memory tasks. Ann N Y Acad Sci. 1998 Dec 21;863:305-22. |[3]Branchek T, et al., Molecular biology and pharmacology of galanin receptors. Ann N Y Acad Sci. 1998 Dec 21;863:94-107.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported