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M40 (TFA)

CAT: 0804-HY-P1025A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1025A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas[1][2][3].
UNSPSC
12352209
Target
Neuropeptide Y Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/m40-tfa.html
Purity
98.33
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(N2[C@@H](CCC2)C(N3[C@@H](CCC3)C(N4[C@@H](CCC4)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC(CNC([C@H](C)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@@H](NC(CN)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F.[x]
Molecular Formula
C95H146N22O24.xC2HF3O2
Molecular Weight
1980.31 (free base)
References & Citations
[1]Narváez JA, et al., The galanin receptor antagonist M40 blocks the central cardiovascular actions of the galanin N-terminal fragment (1-15) . Eur J Pharmacol. 2000 Jul 7;399 (2-3) :197-203.|[2]McDonald MP, et al., Galanin inhibits performance on rodent memory tasks. Ann N Y Acad Sci. 1998 Dec 21;863:305-22. |[3]Branchek T, et al., Molecular biology and pharmacology of galanin receptors. Ann N Y Acad Sci. 1998 Dec 21;863:94-107.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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