DBCO-NHS ester 2

• Description :

  DBCO-NHS ester 2 is a cleavable linker that is used for making antibody-drug conjugate (ADC) . DBCO-NHS ester 2 is a derivative of Dibenzylcyclooctyne (DBCO) used in copper-free click chemistry[1]. DBCO-NHS ester 2 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• Product Name Alternative :

  PQQ; Methoxatin

• UNSPSC :

  12352203

• Hazard Statement :

  H315, H319, H335

• Target :

  ADC Linker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dbco-nhs-ester-2.html

• Purity :

  99.69

• Solubility :

  DMSO : 14.29 mg/mL (ultrasonic)

• Smiles :

  O=C1CCC(N1OC(CCCCC(N2C3=CC=CC=C3C#CC(C=CC=C4)=C4C2)=O)=O)=O

• Molecular Formula :

  C25H22N2O5

• Molecular Weight :

  430.45

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Tang F, et al. Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody-drug conjugates. Nat Protoc. 2017 Aug;12 (8) :1702-1721.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• CAS Number :

  [1384870-47-6]