DBCO-PEG5-NHS ester

• UNSPSC Description:

  DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1][2]. DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• Target Antigen:

  ADC Linker; PROTAC Linkers

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related;PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dbco-peg5-nhs-ester.html

• Purity:

  95.06

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCNC(CCC(N2C3=CC=CC=C3C#CC4=CC=CC=C4C2)=O)=O

• Molecular Weight:

  693.74

• References & Citations:

  [1]Craig L. Duvall, et al. Conjugation of lipophilic albumin-binding moiety to rna for improved carrier-free in vivo pharmacokinetics and gene silencing. US20180064749A1.|[2]Samantha M Sarett, et al. Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6490-E6497.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported

• CAS Number:

  2144395-59-3