DBCO-PEG5-NHS ester

• Description:

  DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1][2]. DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• UNSPSC:

  12352203

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ADC Linker; PROTAC Linkers

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dbco-peg5-nhs-ester.html

• Purity:

  95.06

• Solubility:

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCNC(CCC(N2C3=CC=CC=C3C#CC4=CC=CC=C4C2)=O)=O

• Molecular Formula:

  C36H43N3O11

• Molecular Weight:

  693.74

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Craig L. Duvall, et al. Conjugation of lipophilic albumin-binding moiety to rna for improved carrier-free in vivo pharmacokinetics and gene silencing. US20180064749A1.|[2]Samantha M Sarett, et al. Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing. Proc Natl Acad Sci U S A. 2017 Aug 8;114 (32) :E6490-E6497.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Alkyl/ether Linkers; Cleavable Linker; PEG Linkers

• CAS Number:

  2144395-59-3