STX-0119

• Description:

  STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM[1].

• UNSPSC:

  12352005

• Target:

  STAT

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/stx-0119.html

• Concentration:

  10mM

• Purity:

  98.40

• Solubility:

  DMSO : 13.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C (C1=CC (C2=CC=CC=C2) =NC3=C1C=CC=C3) NC4=NN=C (C5=CC=CO5) O4

• Molecular Formula:

  C22H14N4O3

• Molecular Weight:

  382.37

• References & Citations:

  [1]Matsuno K, et al. Identification of a New Series of STAT3 Inhibitors by Virtual Screening. ACS Med Chem Lett. 2010 Jul 13;1 (8) :371-5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  STAT3

• CAS Number:

  851095-32-4