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BI-0115

CAT: 0804-HY-23999-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-23999-01Size:1 mg
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Description
BI-0115 is a selective inhibitor of LOX-1 (IC50=5.4 μM) that blocks cellular uptake of oxLDL. BI-0115 binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain[1].
CAS Number
4929-23-1
UNSPSC
12352005
Target
LOX-1
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bi-0115.html
Purity
99.71
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(CCC)C2=CC=CN=C2NC3=CC(Cl)=CC=C13
Molecular Formula
C15H14ClN3O
Molecular Weight
287.74
References & Citations
[1]Schnapp, G., et al. A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state. Commun Chem 3, 75 (2020) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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