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Tramiprosate-d6

CAT: 0804-HY-14602S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14602S-01Size:1 mg
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Description
Tramiprosate-d6 is the deuterium labeled Tramiprosate. Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects[1][2][3].
CAS Number
1131576-06-1
Product Name Alternative
Homotaurine-d6; 3-Amino-1-propanesulfonic acid-d6
UNSPSC
12352211
Target
Amyloid-β
Type
Isotope-Labeled Compounds
Related Pathways
Neuronal Signaling
Field of Research
Cancer
Purity
98.0
Solubility
H2O : 50mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(C([2H])([2H])C([2H])([2H])C([2H])([2H])N)(O)=O
Molecular Formula
C3H3D6NO3S
Molecular Weight
145.21
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Wu S et al. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. Neuropharmacology. 2014 Aug;83:107-17.|[3]Francine Gervais, et al. Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis. Neurobiol Aging. 2007 Apr;28 (4) :537-47.|[4]R G Fariello, et al. Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. Neurology. 1982 Mar;32 (3) :241-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Chemical Information

3-Aminopropane-d6-sulfonic acid
CAS Number1131576-06-1
PubChem CID25253924
IUPAC Name3-amino-1,1,2,2,3,3-hexadeuteriopropane-1-sulfonic acid
Molecular FormulaC3H9NO3S
Molecular Weight145.21
XLogP-3.8
Topological Polar Surface Area88.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count8
Formal Charge0
Complexity133
SMILES
[2H]C([2H])(C([2H])([2H])N)C([2H])([2H])S(=O)(=O)O
InChI
InChI=1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)/i1D2,2D2,3D2
InChIKey
SNKZJIOFVMKAOJ-NMFSSPJFSA-N
Chemical Structure
2D Structure
2D structure of 3-Aminopropane-d6-sulfonic acid
CAS: 1131576-06-1
CID: 25253924
Formula: C3H9NO3S
MW: 145.21
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight145.21
XLogP3-3.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass145.06797480
Monoisotopic Mass145.06797480
Topological Polar Surface Area88.8 Ų
Heavy Atom Count8
Formal Charge0
Complexity133
Isotope Atom Count6
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B7446-5.1Tramiprosate
256955Tramiprosate discontinued. See 278965
AR-H07628-01Homotaurine-d4 (Tramiprosate-d4)
AR-H07627-01Homotaurine (Tramiprosate, Acamprosate EP Impurity A)
CS-O-59102Fruquintinib-d6 (Dimethoxy-d6)
UYB80274-01Bezafibrate-d6 (dimethyl-d6)
TMIJ-0459-01Methamidophos-d6 (dimethyl-d6)
RM-P052032-01Pentoxifylline-D6 (Dimethyl-D6)
TRC-M260801-5MGMethoxychlor-d6 (dimethoxy-d6)
AR-T06190-01Tucatinib-d6 (Irbinitinib-d6)

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