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Tramiprosate

CAT: 0804-HY-14602-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14602-01Size:500 mg
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Description
Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects[1][2][3].
CAS Number
3687-18-1
Product Name Alternative
Homotaurine; 3-Amino-1-propanesulfonic acid
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Amyloid-β
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Tramiprosate.html
Purity
98.0
Solubility
DMSO : 1 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)
Smiles
NCCCS(=O)(O)=O
Molecular Formula
C3H9NO3S
Molecular Weight
139.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Wu S et al. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. Neuropharmacology. 2014 Aug;83:107-17.|[2]Francine Gervais, et al. Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis. Neurobiol Aging. 2007 Apr;28 (4) :537-47.|[3]R G Fariello, et al. Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. Neurology. 1982 Mar;32 (3) :241-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 4

Alternative Products

CatalogName
B7446-5.1Tramiprosate
256955Tramiprosate discontinued. See 278965
AR-H07628-01Homotaurine-d4 (Tramiprosate-d4)
AR-H07627-01Homotaurine (Tramiprosate, Acamprosate EP Impurity A)

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