Mal-Pc

• Description :

  Mal-Pc is a versatile molecular photosensitizer designed based phthalocyanine and maleimides. Mal-Pc can react with GSH to deplete GSH and reduce aggregation, thereby improving ROS (Reactive Oxygen Species) -mediated effect of photodynamic therapy (PDT) in cancer cells[1].

• UNSPSC :

  12352005

• Target :

  Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mal-pc.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N1CCC(O[Si]234(OC(CCN5C(C=CC5=O)=O)=O)N6C(C7=C(C6=NC(C8=C9C=CC=C8)=[N]4C9=N%10)C=CC=C7)=NC(C%11=C%12C=CC=C%11)=[N]2C%12=NC%13=C(C=CC=C%14)C%14=C%10N%133)=O)C=CC1=O

• Molecular Formula :

  C46H28N10O8Si

• Molecular Weight :

  876.86

• References & Citations :

  [1]Juanjuan Chen, et al. Novel molecular photosensitizer with simultaneously GSH depletion, aggregation inhibition and accelerated elimination for improved and safe photodynamic therapy. Eur J Med Chem. 2023 Jan 5;245 (Pt 1) :114938.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2670367-74-3]