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Orphenadrine (citrate)

CAT: 0804-HY-B0369A-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0369A-01Size:50 mg
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Description
Orphenadrine citrate is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine citrate relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine citrate is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases[1][2].
CAS Number
4682-36-4
UNSPSC
12352005
Hazard Statement
H301
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/orphenadrine-citrate.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)
Smiles
CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C.O=C(CC(C(O)=O)(O)CC(O)=O)O
Molecular Formula
C24H31NO8
Molecular Weight
461.50
Precautions
H301
References & Citations
[1]Pubill D, et al. Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo. Br J Pharmacol. 2001 Feb;132 (3) :693-702. |[2]Kornhuber J, et al. Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies. J Neural Transm Gen Sect. 1995;102 (3) :237-46.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
NMDA Receptor

Chemical Information

Orphenadrine Citrate

Orphenadrine citrate is a citrate salt which comprises equimolar amounts of orphenadrine and citric acid. It has a role as a H1-receptor antagonist, a muscarinic antagonist, a parasympatholytic, a muscle relaxant and a NMDA receptor antagonist. It contains an orphenadrine.

CAS Number4682-36-4
PubChem CID83823
IUPAC NameN,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid
Molecular FormulaC24H31NO8
Molecular Weight461.5
Topological Polar Surface Area145
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count11
Heavy Atom Count33
Formal Charge0
Complexity488
SMILES
CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
InChI
InChI=1S/C18H23NO.C6H8O7/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-12,18H,13-14H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChIKey
MMMNTDFSPSQXJP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Orphenadrine Citrate
CAS: 4682-36-4
CID: 83823
Formula: C24H31NO8
MW: 461.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight461.5
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count11
Exact Mass461.20496695
Monoisotopic Mass461.20496695
Topological Polar Surface Area145 Ų
Heavy Atom Count33
Formal Charge0
Complexity488
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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