Orphenadrine (hydrochloride)

Orphenadrine (hydrochloride)

• CAS Number: 341-69-5
• UNSPSC Description: Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases[1][2].
• Target Antigen: iGluR
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/Orphenadrine-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C.[H]Cl
• Molecular Weight: 305.84
• References & Citations: [1]Pubill D, et al. Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo. Br J Pharmacol. 2001 Feb;132(3):693-702. |[2]Kornhuber J, et al. Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies. J Neural Transm Gen Sect. 1995;102(3):237-46.
• Shipping Conditions: Room temperature
• Clinical Information: Launched