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Orphenadrine (hydrochloride)

CAT: 0804-HY-B1126Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1126Size:1 Each
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Description
Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases[1][2].
CAS Number
341-69-5
UNSPSC
12352005
Hazard Statement
H301
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Orphenadrine-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C.[H]Cl
Molecular Formula
C18H24ClNO
Molecular Weight
305.84
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Pubill D, et al. Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo. Br J Pharmacol. 2001 Feb;132 (3) :693-702. |[2]Kornhuber J, et al. Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies. J Neural Transm Gen Sect. 1995;102 (3) :237-46.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
NMDA Receptor

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