GX-936

CAT: 0804-HY-123414Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-123414Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GX-936 (PF-05196233), a potent and Nav1.7-subtype selective inhibitor, binds to the activated state of voltage-sensor domain IV (VSD4) [1][2][3].
CAS Number
[1235406-09-3]
Product Name Alternative
PF-05196233
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gx-936.html
Smiles
O=S(C1=CC=C(C(C#N)=C1)OC2=CC=C(C=C2C3=CC=NN3C4CN(C4)CC)C(F)(F)F)(NC5=NC=NS5)=O
Molecular Formula
C24H20F3N7O3S2
Molecular Weight
575.59
References & Citations
[1]R Ian Storer, et al. Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes. Bioorg Med Chem Lett. 2017 Nov 1;27 (21) :4805-4811.|[2]Shivani Ahuja, et al. Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science. 2015 Dec 18;350 (6267) :aac5464. |[3]Jian Payandeh, et al. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7. Handb Exp Pharmacol. 2018:246:271-306.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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