SCH 221510

• Description :

  SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC50 of 12 nM and Ki of 0.3 nM. SCH 221510 shows an anxiolytic-like effect[1].

• UNSPSC :

  12352005

• Target :

  Opioid Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/sch-221510.html

• Concentration :

  10mM

• Purity :

  99.00

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O[C@](C[C@H]1CC2)(C3=CC=CC=C3)C[C@H]2N1C(C4=C(C=CC=C4)C)C5=C(C=CC=C5)C

• Molecular Formula :

  C28H31NO

• Molecular Weight :

  397.55

• References & Citations :

  [1]Varty GB, et al. The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis (2-methylphenyl) methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510) . J Pharmacol Exp Ther. 2008 Aug;326 (2) :672-82.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NOP Receptor/ORL1

• CAS Number :

  [322473-89-2]