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DNMT3A-IN-1

CAT: 0804-HY-144433-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-144433-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DNMT3A-IN-1 (compound 1) is an effective and selective DNMT3A inhibitor. DNMT3A-IN-1 exhibits inhibitory activity against DNMT3A, with KI values ranging from 9.16 to 18.85 μM (AdoMet) and 11.37 to 23.34 μM (poly dI-dC) . DNMT3A-IN-1 can induce apoptosis in acute myeloid leukemia (AML) cell lines (Apoptosis) [1][2].
CAS Number
1403598-56-0
UNSPSC
12352005
Target
DNA Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dnmt3a-in-1.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(C2CCCCCC2)N=C(C1(C)C)C3=CC(OCCCCOC4=CC=C(C5=NN=NN5)C=C4)=C(OC)C=C3
Molecular Formula
C30H38N6O4
Molecular Weight
546.66
References & Citations
[1]Huang S, et al. A novel class of selective non-nucleoside inhibitors of human DNA methyltransferase 3A. Bioorg Med Chem Lett. 2021; 40:127908.|[2]Sandoval JE, Ramabadran R, Stillson N, et al. First-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein-Protein Interactions and Induce Acute Myeloid Leukemia Cell Differentiation. J Med Chem. 2022;65 (15) :10554-10566.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DNMT3

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