4'-Hydroxy diclofenac

• Description :

  4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9) . 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H318

• Target :

  Drug Metabolite

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/4-hydroxy-diclofenac.html

• Concentration :

  10mM

• Purity :

  99.70

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=C(O)C=C2Cl

• Molecular Formula :

  C14H11Cl2NO3

• Molecular Weight :

  312.15

• Precautions :

  H301, H318

• References & Citations :

  [1]J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56 (1) :65-8.|[2]Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice With Humanized Livers. Drug Metab Dispos. 2015 Mar;43 (3) :309-16.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [64118-84-9]