WL 47 dimer

• Description :

  WL 47 dimer (ligand 1) is a caveolin-1 (CAV-1) ligand with high affinity, selectivity and oligomer dissociation activity. WL 47 dimer simultaneously occupies two binding sites of CAV-1, inducing the dissociation of oligomers. WL 47 dimer has 7500-fold improved affinity compared to its T20 parent ligand and an 80% decrease in sequence length. WL 47 dimer can be used to permit targeted study of CAV-1 function[1].

• UNSPSC :

  12352209

• Target :

  Others

• Type :

  Peptides

• Related Pathways :

  Others

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/wl-47-dimer.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@@H](N)CSSC[C@H](N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCSC)=O)CC1=CNC2=CC=CC=C12)=O)CO)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCSC)=O)CC3=CNC4=CC=CC=C34)=O)CO

• Molecular Formula :

  C80H130N24O18S4

• Molecular Weight :

  1844.30

• References & Citations :

  [1]Gilliam A J H, et al. Affinity-guided design of caveolin-1 ligands for deoligomerization[J]. Journal of medicinal chemistry, 2016, 59 (8) : 4019-4025.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported