(E) -Guanabenz

• Description:

  (E) -Guanabenz ((E) -Wy-8678) is an orally active central α2-adrenoceptor agonist. (E) -Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E) -Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E) -Guanabenz can be used for researching hypertension and Parkinson disease[1][2].

• Product Name Alternative:

  (E) -Wy-8678

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/e-guanabenz.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=C (/C=N/NC (N) =N) C (Cl) =CC=C1

• Molecular Formula:

  C8H8Cl2N4

• Molecular Weight:

  231.08

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Sun X, et al. Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease. Exp Neurol. 2018 May;303:95-107.|[2]Xie J, et al. LC-MS/MS determination of guanabenz E/Z isomers and its application to in vitro and in vivo DMPK profiling studies. J Pharm Biomed Anal. 2021 Oct 25;205:114331.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  α adrenergic receptor

• CAS Number:

  60329-03-5