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(E) -Guanabenz

CAT: 0804-HY-W263279Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W263279Size:1 Each
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Description
(E) -Guanabenz ((E) -Wy-8678) is an orally active central α2-adrenoceptor agonist. (E) -Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E) -Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E) -Guanabenz can be used for researching hypertension and Parkinson disease[1][2].
CAS Number
60329-03-5
Product Name Alternative
(E) -Wy-8678
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/e-guanabenz.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1
Molecular Formula
C8H8Cl2N4
Molecular Weight
231.08
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Sun X, et al. Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease. Exp Neurol. 2018 May;303:95-107.|[2]Xie J, et al. LC-MS/MS determination of guanabenz E/Z isomers and its application to in vitro and in vivo DMPK profiling studies. J Pharm Biomed Anal. 2021 Oct 25;205:114331.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
α adrenergic receptor

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