Guanabenz (Acetate)

• Description:

  Guanabenz (Acetate) (BR-750) is an alpha-2 selective adrenergic agonist used as an antihypertensive agent.

• Product Name Alternative:

  BR-750; Wy8678 acetate

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease; Endocrinology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Guanabenz-Acetate.html

• Concentration:

  10mM

• Purity:

  98.93

• Solubility:

  DMSO : ≥ 51 mg/mL|H2O : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1.CC(O)=O

• Molecular Formula:

  C10H12Cl2N4O2

• Molecular Weight:

  291.13

• Precautions:

  H301

• References & Citations:

  [1]Walker, B.R., L.E. Hare, and M.W. Deitch, Comparative antihypertensive effects of guanabenz and clonidine. J Int Med Res, 1982. 10 (1) : p. 6-14.|[2]Bonham, A.C., et al., Studies on the mechanism of the central antihypertensive effect of guanabenz and clonidine. J Hypertens Suppl, 1984. 2 (3) : p. S543-6.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [23256-50-0]