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Guanabenz

CAT: 0804-HY-12724-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12724-01Size:5 mg
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Description
Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure[1][2][3].
CAS Number
5051-62-7
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H361
Target
Adrenergic Receptor; Parasite
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/guanabenz.html
Concentration
10mM
Purity
99.85
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1
Molecular Formula
C8H8Cl2N4
Molecular Weight
231.08
Precautions
H302+H312+H332, H361
References & Citations
[1]Christiane Neuber, et al. Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes. PLoS One. 2014 Jun 3;9 (6) :e98893.|[2]Jennifer Martynowicz, et al. Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation. mBio. 2019 Apr 30;10 (2) :e00381-19.|[3]T Baum, et al. Studies on the centrally mediated hypotensive activity of guanabenz. Eur J Pharmacol. 1976 May;37 (1) :31-44.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Toxoplasma

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