Guanabenz

• Description:

  Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302+H312+H332, H361

• Target:

  Adrenergic Receptor; Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; GPCR/G Protein; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/guanabenz.html

• Concentration:

  10mM

• Purity:

  99.85

• Solubility:

  DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1

• Molecular Formula:

  C8H8Cl2N4

• Molecular Weight:

  231.08

• Precautions:

  H302+H312+H332, H361

• References & Citations:

  [1]Christiane Neuber, et al. Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes. PLoS One. 2014 Jun 3;9 (6) :e98893.|[2]Jennifer Martynowicz, et al. Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation. mBio. 2019 Apr 30;10 (2) :e00381-19.|[3]T Baum, et al. Studies on the centrally mediated hypotensive activity of guanabenz. Eur J Pharmacol. 1976 May;37 (1) :31-44.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  Toxoplasma

• CAS Number:

  [5051-62-7]