Guanabenz

• UNSPSC Description:

  Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure[1][2][3].

• Target Antigen:

  Adrenergic Receptor; Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;GPCR/G Protein;Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/guanabenz.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1

• Molecular Weight:

  231.08

• References & Citations:

  [1]Christiane Neuber, et al. Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes. PLoS One. 2014 Jun 3;9(6):e98893.|[2]Jennifer Martynowicz, et al. Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation. mBio. 2019 Apr 30;10(2):e00381-19.|[3]T Baum, et al. Studies on the centrally mediated hypotensive activity of guanabenz. Eur J Pharmacol. 1976 May;37(1):31-44.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  5051-62-7