Sirtuin-IN-2

• Description:

  Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, which is a key target for leukemia and breast cancer[1].

• UNSPSC:

  12352211

• Target:

  Sirtuin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sirtuin-in-2.html

• Smiles:

  S=C(NCCC(O)=O)NCCCC[C@H](NC(OCC1=CC=CC=C1)=O)C(N[C@@H](CCCNC(N)=N)C(NCCCC)=O)=O

• Molecular Formula:

  C28H46N8O6S

• Molecular Weight:

  622.78

• References & Citations:

  [1]Hansen TN, et al. Mechanism-based inactivators of sirtuin 5: A focused structure-activity relationship study. Bioorg Med Chem Lett. 2025 Jan 1;115:130017.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  SIRT5