Recombinant Human Laminin411 E8 Protein

Laminins are large molecular weight glycoproteins constituted by the assembly of three disulfide-linked polypeptides, the α, β and γ chains. The human genome encodes 11 genetically distinct laminin chains. Structurally, laminin chains differ by the number, size and organization of a few constitutive domains, endowing the various members of the laminin family with common and unique important functions. In particular, laminins are indispensable building blocks for cellular networks physically bridging the intracellular and extracellular compartments and relaying signals critical for cellular behavior, and for extracellular polymers determining the architecture and the physiology of basement membranes. Laminins are glycoproteins with both common and specific functions. One common and most important function of laminins is to interact with receptors anchored in the plasma membrane of cells adjacent to basement membranes. In doing so laminins regulate multiple cellular activities and signaling pathways. Laminin-411, as a progression-related tumor microenvironment marker, may be a promising therapeutic target. Uncovering the molecular ties between laminin-411, angiogenic factors, and signaling pathways that promote tumor angiogenesis and CSC survival may significantly improve brain cancer therapy.

Laminin411; LN411

Q16363-2 & P07942 & P11047

N-6His &N-Flag&N-HA

HEK293 Cells

<0.01 EU/μg as determined by LAL test.

Liquid

92.7 & 26.4 & 28.5kDa

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles and use a manual defrost freezer.

Glu629-His1449 & Leu1561–Leu1786 & Asn1364–Pro1609

Supplied as a 0.2 μm filtered solution of PBS, pH7.4.