Recombinant Human Laminin121 E8 Protein

Laminins are large molecular weight glycoproteins constituted by the assembly of three disulfide-linked polypeptides, the α, β and γ chains. The human genome encodes 11 genetically distinct laminin chains. Structurally, laminin chains differ by the number, size and organization of a few constitutive domains, endowing the various members of the laminin family with common and unique important functions. In particular, laminins are indispensable building blocks for cellular networks physically bridging the intracellular and extracellular compartments and relaying signals critical for cellular behavior, and for extracellular polymers determining the architecture and the physiology of basement membranes. Laminins are glycoproteins with both common and specific functions. One common and most important function of laminins is to interact with receptors anchored in the plasma membrane of cells adjacent to basement membranes. In doing so laminins regulate multiple cellular activities and signaling pathways. Laminin121 is one of the α1 chain containing laminins and the other isoform is laminin-111, which is the first identified laminin isolated from the EHS tumor and from teratocarcinoma cells.

Laminin 121; LN121

P25391 & P55268 & P11047

N-6His &N-Flag&N-HA

HEK293 Cells

<0.01 EU/μg as determined by LAL test.

Liquid

91.4 & 25.8 & 28.5kDa

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles and use a manual defrost freezer.

Phe1878-Gln2700 & Leu1573–Gln1798 & Asn1364–Pro1609

Supplied as a 0.2 μm filtered solution of PBS, pH7.4.