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BRD7539

CAT: 0804-HY-116736Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-116736Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BRD7539 is a PfDHODH inhibitor (IC50 = 0.033 μM) . BRD7539 has potent activity against both multidrug-resistant asexual blood-stage (P. falciparum, Dd2 strain, EC50 = 0.010 μM) and liver-stage (P. berghei, EC50 = 0.015 μM) parasites[1].
CAS Number
[2057420-00-3]
UNSPSC
12352101
Target
Dihydroorotate Dehydrogenase; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/brd7539.html
Smiles
N#C[C@@H]1[C@H](C2=CC=C(C=C2)C#CC3=CC(F)=CC=C3)[C@H](N1C(NCCC)=O)CO
Molecular Formula
C23H22FN3O2
Molecular Weight
391.44
References & Citations
[1]Maetani M, et al. Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase. ACS Med Chem Lett. 2017 Feb 27;8 (4) :438-442.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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