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BRD7586

CAT: 0804-HY-148730-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-148730-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BRD7586 is a potent and selective Streptococcus pyogenes Cas9 (SpCas9) inhibitor. BRD7586 specifically engages SpCas9 but not Cas12a in cells and enhances SpCas9 specificity at multiple loci. BRD7586 inhibits SpCas9 at multiple genomic loci irrespective of the mode of SpCas9 delivery[1].
CAS Number
[895460-70-5]
UNSPSC
12352005
Target
Bacterial; CRISPR/Cas9
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brd7586.html
Purity
99.03
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(CCS(=O)(C1=CC=C(C=C1)Cl)=O)NC2=NC(C3=CC=NC=C3)=CS2
Molecular Formula
C17H14ClN3O3S2
Molecular Weight
407.89
References & Citations
[1]Lim D, et al. A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules. Nat Cell Biol. 2022 Dec;24 (12) :1766-1775.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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