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BRD7552

CAT: 0804-HY-19694-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-19694-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BRD7552, a potent PDX1 transcription factor inducer, upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases insulin expression. PDX1 is a key transcription factor involved in pancreas development and β cell function[1].
CAS Number
[1137359-47-7]
UNSPSC
12352005
Target
Insulin Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/BRD7552.html
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC[C@@H](O1)[C@@H](OC(NC2=CC=C(C(OCC)=O)C=C2)=O)[C@H](OC(NC3=CC=C(OCO4)C4=C3)=O)[C@@H](OC(NC5=CC=C(OCO6)C6=C5)=O)[C@H]1OC
Molecular Formula
C33H33N3O15
Molecular Weight
711.63
References & Citations
[1]Yuan Y, et al. A small-molecule inducer of PDX1 expression identified by high-throughput screening [published correction appears in Chem Biol. 2014 Feb 20;21 (2) :306]. Chem Biol. 2013;20 (12) :1513-1522.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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