MS-436

• Description:

  MS-436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated Ki of 30-50 nM) with preference for the first bromodomain over the second. MS-436 effectively blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC50values are 3.8 and 4.9 μM, respectively) . MS-436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression.

• Purity:

  98%

• Format:

  Solid

• Molecular Formula:

  C18H17N5O3S

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  At least 6 months at -20°C.

• Calculated Molecular Weight:

  383.4 Da

• CAS Number:

  1395084-25-9