GSK-A1

CAT: 0804-HY-125118-01Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-125118-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

GSK-A1 is a selective type III phosphatidylinositol 4-kinase PI4KA (PI4KIIIα) inhibitor with a pIC50 of 8.5-9.8. GSK-A1 inhibits PtdIns (4,5) P2 resynthesis with an IC50 of about 3 nM. GSK-A1 potently decreases the levels of PtdIns (4) P with a negligible effect on PtdIns (4,5) P2. GSK-A1 has the potential for anti-hepatitis C virus (HCV) research[1].

CAS Number

1416334-69-4

UNSPSC

12352005

Target

HCV; PI4K

Type

Reference compound

Related Pathways

Anti-infection; PI3K/Akt/mTOR

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/gsk-a1.html

Purity

99.04

Solubility

DMSO : ≥ 2 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=S(C1=CC(C2=CC=C3N=C(N)N(C4=CC=C(N5CCOCC5)C=C4)C3=C2)=CN=C1OC)(NC6=CC=CC=C6F)=O

Molecular Formula

C29H27FN6O4S

Molecular Weight

574.63

References & Citations

[1]Naveen Bojjireddy, et al. Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels. J Biol Chem. 2014 Feb 28;289 (9) :6120-32.|[2]Smulders L, et al. Phosphatidylinositol Monophosphates Regulate the Membrane Localization of HSPA1A, a Stress-Inducible 70-kDa Heat Shock Protein. Biomolecules. 2022 Jun 20;12 (6) :856. |[3]Jiang X, et al. Targeting PI4KA sensitizes refractory leukemia to chemotherapy by modulating the ERK/AMPK/OXPHOS axis. Theranostics. 2022 Oct 3;12 (16) :6972-6988. |[4]Li FL, et al. Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides. Nat Chem Biol. 2022 Oct;18 (10) :1076-1086.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PI4K; PI4KIIIα; PI4KIIIβ

Related Products

Catalog	Name
HY-P991051-01	GSK-2330811
HY-P990592-01	GSK-3050002
HY-108081	GSK-958108
HY-117658-01	GSK-114
HY-15192-01	GSK 650394
HY-18665-01	GSK-5959
HY-121594	GSK-269984B
HY-P990593-01	GSK-4381562
HY-147312-01	GSK-1520489A
HY-19924	GSK-1440115

Alternative Products

Catalog	Name
BA1858-1	GSK-A1
T25471-01	GSK-A
MBS131437	GSK163090 (GSK-163090; GSK 163090)
MBS131519	GSK369796 (GSK-369796, GSK 369796)
A3450-5.1	GSK-923295
BA4485-5.1	GSK-25
B7751-100	GSK 2193874
A3445-5.1	GSK 525768A
BA6566-50	GSK-7975A
BA8749-25	GSK-F1

GSK-A1

Related Products

Alternative Products

Popular Products