α-conotoxin-IMI

• Description:

  α-conotoxin IMI (alpha-conotoxin IMI) is a conopeptide that has been isolated from the venom of the cone snail Conus imperialis. α-conotoxin IMI acts on postsynaptic membranes, and binds onto and inhibits nicotinic acetylcholine receptors (nAChR) . α-conotoxin IMI is a selective blocker of α7 homomeric nicotinic acetylcholine receptors (IC50 ~ 200 nM) . It has no effect on nAChRs composed of α2/ß2, α3/ß2, α4/ß2, α2/ß4, α3/ß4, or α4/ß4 subunits. α-conotoxins IMI acts independently of voltage value. This toxin is highly active against the neuromuscular receptor in frog.

• Specifications:

  α7 nAChR selective blocker

• Target:

  Acetylcholine receptors

• Sequence:

  GCCSDPRCAWRC

• Peptide Number:

  08CON011

• Disulfide Bonds:

  Cys2-Cys8 ; Cys3-Cys12

• N Terminal Sequence:

  H

• C Terminal Sequence:

  NH2

• CAS Number:

  156467-85-5