α-conotoxin-MI

• Description:

  α-conotoxin MI (alpha-conotoxin MI) is a conotoxin that has been isolated from the venom of the cone snail Conus magus. α-conotoxin MI is a competitive antagonist of the muscle-type nicotinic acetylcholine receptors (nAChR) such as α-conotoxin GI or d-Turbocurarine. It binds to the receptor with a Kd value ~0,94nM. α-conotoxin MI allows to distinguish between the two agonist sites as it binds 10,000-fold more tightly to the α/δ than to the α/γ site.

• Specifications:

  α/δ site of the muscle-type nAChR blocker

• Target:

  Acetylcholine receptors

• Sequence:

  GRCCHPACGKNYSC

• Peptide Number:

  08CON012

• Disulfide Bonds:

  Cys3-Cys8; Cys4-Cys14

• N Terminal Sequence:

  H

• C Terminal Sequence:

  NH2

• CAS Number:

  83481-45-2