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α-conotoxin-PeIA

CAT: 0466-13CON017-00500Size: 0.5 mgDry Ice: NoHazardous: No
CAT#:0466-13CON017-00500Size:0.5 mg
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Description
α-conotoxin PeIA is a conotoxin that has been isolated from the venom of Conus pergrandis. α-conotoxin PeIA discriminates between α9α10 and α7 nicotinic acetylcholine receptors (AChRs) with IC50 values of 7-50 nM (depending of the authors) and 1.8 µM, respectively. The toxin is also known to block α3β2 nicotinic AChRs (with an IC50 of 97 nM) and block voltage-gated N-type Ca2+ channels in rat DRG neurons with an IC50 of 1.1 nM. No significant inhibition of ACh-evoked currents for nicotinic α4β2 and muscle αβγδ AChRs by 1 µM α-conotoxin PeIA was observed. The action of α-conotoxin PeIA is fully reversible after washout of the peptide in the extracellular medium.
Specifications
α9α10 and α7 nAChRs channels discrimination
Target
Acetylcholine receptors
Sequence
GCCSHPACSVNHPELC
Peptide Number
13CON017
Disulfide Bonds
Cys2-Cys8; Cys3-Cys16
N Terminal Sequence
H
C Terminal Sequence
NH2

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