α-conotoxin-PeIA

• Description:

  α-conotoxin PeIA is a conotoxin that has been isolated from the venom of Conus pergrandis. α-conotoxin PeIA discriminates between α9α10 and α7 nicotinic acetylcholine receptors (AChRs) with IC50 values of 7-50 nM (depending of the authors) and 1.8 µM, respectively. The toxin is also known to block α3β2 nicotinic AChRs (with an IC50 of 97 nM) and block voltage-gated N-type Ca2+ channels in rat DRG neurons with an IC50 of 1.1 nM. No significant inhibition of ACh-evoked currents for nicotinic α4β2 and muscle αβγδ AChRs by 1 µM α-conotoxin PeIA was observed. The action of α-conotoxin PeIA is fully reversible after washout of the peptide in the extracellular medium.

• Specifications:

  α9α10 and α7 nAChRs channels discrimination

• Target:

  Acetylcholine receptors

• Sequence:

  GCCSHPACSVNHPELC

• Peptide Number:

  13CON017

• Disulfide Bonds:

  Cys2-Cys8; Cys3-Cys16

• N Terminal Sequence:

  H

• C Terminal Sequence:

  NH2