ω-Conotoxin-MVIIC

CAT: 0466-08CON002-00500Size: 0.5 mgDry Ice: NoHazardous: No
CAT#:0466-08CON002-00500Size:0.5 mg
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Description
ω-conotoxin MVIIC (omega conotoxin MVIIC) is a conotoxin that has been isolated from the venom of the cone Conus magus. ω-conotoxin MVIIC is a blocker of P/Q (IC50=35 nM) and N-type calcium channels. It inhibits presynaptic Ca2+ channels, including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes, the P-type Ca2+ channels in cerebellar Purkinje cells, and a significant fraction of ω-conotoxin GVIA-resistant currents in hippocampal CA1 neurons. ω-conotoxin MVIIC also presents an inhibition of ω-conotoxin GVIA-resistant depolarization-induced neurotransmitter release in cerebellar neurons of rats.
CAS Number
147794-23-8
Specifications
Blocker of P/Q and N-type Ca2+ channels
Target
Ca channels
Sequence
CKGKGAPCRKTMYDCCSGSCGRRGKC
Peptide Number
08CON002
Disulfide Bonds
Cys1-Cys16; Cys8-Cys20; Cys15-Cys26
N Terminal Sequence
H
C Terminal Sequence
NH2

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