α-conotoxin-IMI

CAT: 0466-08CON011-00500Size: 0.5 mgDry Ice: NoHazardous: No
CAT#:0466-08CON011-00500Size:0.5 mg
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Description
α-conotoxin IMI (alpha-conotoxin IMI) is a conopeptide that has been isolated from the venom of the cone snail Conus imperialis. α-conotoxin IMI acts on postsynaptic membranes, and binds onto and inhibits nicotinic acetylcholine receptors (nAChR) . α-conotoxin IMI is a selective blocker of α7 homomeric nicotinic acetylcholine receptors (IC50 ~ 200 nM) . It has no effect on nAChRs composed of α2/ß2, α3/ß2, α4/ß2, α2/ß4, α3/ß4, or α4/ß4 subunits. α-conotoxins IMI acts independently of voltage value. This toxin is highly active against the neuromuscular receptor in frog.
CAS Number
156467-85-5
Specifications
α7 nAChR selective blocker
Target
Acetylcholine receptors
Sequence
GCCSDPRCAWRC
Peptide Number
08CON011
Disulfide Bonds
Cys2-Cys8 ; Cys3-Cys12
N Terminal Sequence
H
C Terminal Sequence
NH2

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