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αC-Conotoxin-PrXA

CAT: 0466-13CON016-00100Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0466-13CON016-00100Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
αC-Conotoxin PrXA (AlphaC-PrXA) is a conotoxin that was originally isolated from the venom of the fish-hunting Conus parius. αC-Conotoxin PrXA is a highly specific inhibitor of the neuromuscular nAChR. It potently antagonizes mouse muscle adult α1/β1/ε/δ nAChR subunits (IC50 = 1.8 nM) as well as fetal mouse muscle α1/β1/γ/δ nAChR subunits (IC50 = 3 nM) . αC-Conotoxin PrXA competes with α-bungarotoxin for binding at the α/δ and α/γ nAChR subunit interfaces (with higher affinity however for the α/δ subunit interface such as α-conotoxin GI and α-conotoxin MI) . The 3D structure of αC-Conotoxin PrXA is different from other conotoxins that target nAChR and it is most similar to Waglerin-1, a nAChR blocker isolated from a snake venom. αC-Conotoxin PrXA is a useful tool for investigating the structure and physiological role of nAChRs.
Specifications
Selective blocker of muscular nACh receptors
Target
Acetylcholine receptors
Sequence
TYGIYDAKP (Hyp) FSCAGLRGGCVLP (Hyp) NLR (Hyp) KFKE
Peptide Number
13CON016
Disulfide Bonds
Cys13-Cys20
N Terminal Sequence
H
C Terminal Sequence
NH2

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