µ-conotoxin-CnIIIC

• Description:

  µ-conotoxin CnIIIC is a conopeptide that has been isolated from the venom of the marine cone snail Conus consors. µ-conotoxin CnIIIC has been described to exhibit a myorelaxing effect through specific blockade of the skeletal muscle Nav1.4 channels (IC50 = 1.4 nM) . µ-conotoxin CnIIIC also appears to block Nav1.2 channels (1 µM) and mildly Nav1.7. In contrast, Nav1.5 and Nav1.8 are insensitive to the action of the toxin. µ-conotoxin CnIIIC is also described to block the α3β2 nicotinic acetylcholine receptor (IC50= 450 nM) and to lesser extents the α7 and α4β2 subtypes and completely inhibits twitch tension in isolated mouse hemidiaphragms (IC50 = 150 nM) . This peptide is a valuable tools to study Nav1.4 channels.

• Specifications:

  Nav1.4 channels

• Target:

  Na channels

• Sequence:

  GCCNGPKGCSSKWCRDHARCC

• Peptide Number:

  CON021

• Disulfide Bonds:

  Cys3-Cys15; Cys4-Cys21; Cys10-Cys22

• N Terminal Sequence:

  PQ

• C Terminal Sequence:

  NH2

• CAS Number:

  936616-33-0