Products for Research Use Only
RegisterLogin

WAY-100635

CAT: 0804-HY-10349-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-10349-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
WAY-100635 is a potent and selective 5-HT1A Receptor antagonist with a pIC50 of 8.87, an apparent pA2 of 9.71. WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 is also a potent dopamine D4 receptor agonist[1][2][3].
CAS Number
162760-96-5
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/way-100635.html
Purity
99.44
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
O=C(N(C1=NC=CC=C1)CCN2CCN(CC2)C3=CC=CC=C3OC)C4CCCCC4
Molecular Formula
C25H34N4O2
Molecular Weight
422.56
References & Citations
[1]Chemel BR, et al. WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology (Berl) . 2006 Oct;188 (2) :244-51.|[2]Mannucci C, et al. Serotonin involvement in Rhodiola rosea attenuation of nicotine withdrawal signs in rats. Phytomedicine. 2012 Sep 15;19 (12) :1117-24.|[3]Al Hussainy R, et al. Design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinatedanalogues of N-{2-[4- (2-methoxyphenyl) piperazin-1-yl]ethyl}-N- (pyridin-2-yl) cyclohexanecarboxamide (WAY-100635) as potential SPECT ligands for the 5-HT1A receptor. J Med Chem. 2011 May 26;54 (10) :3480-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; D4 Receptor; mLAG-3
Citation 01
Biomedicines. 2025 Sep 23;13 (10) :2319.|Chin J Integr Med. 2021 Jul;27 (7) :534-541.|Chin Med. 2024 Jun 15;19 (1) :87.|Int Immunopharmacol. 2024 Feb 15:128:111524.|iScience. 2025 Nov 25;28 (12) :114211.|Nat Neurosci. 2022 Jan;25 (1) :39-49.|Psychopharmacology (Berl) . 2022 Nov;239 (11) :3551-3565.|Psychopharmacology (Berl) . 2024 Nov;241 (11) :2315-2330.

Related Products

CatalogName
HY-117575WAY-100135
HY-117575A-01WAY-100135 (dihydrochloride)
HY-110001(S) -WAY 100135 (dihydrochloride)
HY-171791WAY-166818
HY-169777WAY-214156
HY-12073WAY-255348
HY-10860-01WAY-362692
HY-19381-01WAY-151932
HY-49458WAY-232897
HY-48243-01WAY-381644

Alternative Products

CatalogName
A3933-200WAY-100635
sc-506278WAY 100635
STB67951-01WAY-100635 Maleate
257091-01WAY 100635 maleate
TRC-W498650-100MGWAY 100635 Hydrochloride

Popular Products