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WAY-255348

CAT: 0804-HY-12073Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12073Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
W-255348 is an effective non-steroidal progesterone receptor (PR) antagonist that acquires antagonist activity by binding to and subsequently blocking progesterone induced nuclear accumulation, phosphorylation, and PR promoter interactions. WAY-255348 can be used in the research of reproductive disorders or PR-positive breast cancer[1].
CAS Number
872141-23-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Progesterone Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Smiles
N#CC1=CC=C(N1C)C2=CC3=C(NC(C3(C)C)=O)C(F)=C2
Molecular Formula
C16H14FN3O
Molecular Weight
283.30
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]J. Med. Chem., 2008, 51 (6), pp 1861-1873 "Design, Synthesis, and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5- (7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl) -1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348) "|[2]Yudt MR, et al. Discovery of a novel mechanism of steroid receptor antagonism: WAY-255348 modulates progesterone receptor cellular localization and promoter interactions. Biochem Pharmacol. 2011 Dec 1;82 (11) :1709-19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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