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C-176

CAT: 0804-HY-112906-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112906-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING[1][2].
CAS Number
314054-00-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/C-176.html
Purity
99.45
Solubility
DMSO : 62.5 mg/mL (ultrasonic) |Ethanol : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(I)C=C2
Molecular Formula
C11H7IN2O4
Molecular Weight
358.09
Precautions
H302, H315, H319, H335
References & Citations
[1]Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559 (7713) :269-273.|[2]Zhang LM, et al. STING mediates neuroinflammatory response by activating NLRP3-related pyroptosis in severe traumatic brain injury. J Neurochem. 2022 Sep;162 (5) :444-462.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
CAS Number314054-00-7
PubChem CID1103958
IUPAC NameN-(4-iodophenyl)-5-nitrofuran-2-carboxamide
Molecular FormulaC11H7IN2O4
Molecular Weight358.09
XLogP3
Topological Polar Surface Area88.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count18
Formal Charge0
Complexity325
SMILES
C1=CC(=CC=C1NC(=O)C2=CC=C(O2)[N+](=O)[O-])I
InChI
InChI=1S/C11H7IN2O4/c12-7-1-3-8(4-2-7)13-11(15)9-5-6-10(18-9)14(16)17/h1-6H,(H,13,15)
InChIKey
JBIKQXOZLBLMKI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
CAS: 314054-00-7
CID: 1103958
Formula: C11H7IN2O4
MW: 358.09
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight358.09
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass357.94505
Monoisotopic Mass357.94505
Topological Polar Surface Area88.1 Ų
Heavy Atom Count18
Formal Charge0
Complexity325
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
S6575-100mgC-176
7040/50C 176
A20121-500C-176 500mg
A20121-25C-176 25mg
A20121-100C-176 100mg
A20121-50C-176 50mg
A20121-10C-176 10mg
A20121-5C-176 5mg

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