MA-0204

• Description:

  MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD) [1].

• Product Name Alternative:

  GMX1778 (nicotinate), GMX1777; EB-1627

• UNSPSC:

  12352005

• Target:

  PPAR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/MA-0204.html

• Purity:

  99.31

• Solubility:

  DMSO : 43.33 mg/mL (ultrasonic)

• Smiles:

  O=C(C[C@@H](CCCOC1=CC=CC=C1CN2C(C)=CN=C2C3=CC=C(C=C3)OC(F)(F)F)C)O

• Molecular Formula:

  C25H27F3N2O4

• Molecular Weight:

  476.49

• References & Citations:

  [1]Lagu B, et al. Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD) . ACS Med Chem Lett. 2018 Jul 31;9 (9) :935-940.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PPARβ/δ

• CAS Number:

  [2095128-17-7]