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8-MA-NAD+ (sodium)

CAT: 0804-HY-134305ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-134305ASize:1 Each
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Description
8-MA-NAD+ (sodium) (8-Methylamino-NAD+ (sodium) ) is a derivative of the signaling molecule and enzyme cofactor NAD+. 8-MA-NAD+ (sodium) can be used in the screening of analog-sensitive poly (ADP-ribose) polymerase 1 (PARP1) gatekeeper mutations. 8-MA-NAD+ (sodium) can be used in the synthesis of cyclic ADP-ribose (cADPR) derivatives[1][2].
Product Name Alternative
8-Methylamino-NAD+ (sodium)
UNSPSC
12352005
Target
Endogenous Metabolite
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Smiles
[O-]P(OP(OC[C@H]1O[C@@H](N2C(NC)=NC3=C(N=CN=C32)N)[C@H](O)[C@@H]1O)(O[Na])=O)(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H]([N+]5=CC=CC(C(N)=O)=C5)O4)=O
Molecular Formula
C22H29N8NaO14P2
Molecular Weight
714.45
References & Citations
[1]Gibson BA, et al. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science. 2016 Jul 1;353 (6294) :45-50. |[2]Moreau C, et al. Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. Org Biomol Chem. 2011 Jan 7;9 (1) :278-90.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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