BC-1293

• Target:

  E1/E2/E3 Enzyme

• Related Pathways:

  Ubiquitination

• Purity:

  0.984

• Bioactivity:

  BC-1293 is an inhibitor of the E3 ligase subunit FBXO24 that acts by disrupting the interaction between FBXO24 and aspartyl-tRNA synthetase (DARS2) . BC-1293 treatment results in increased levels of DARS2, showing its capacity to stabilize this essential enzyme. Furthermore, BC-1293 elevates levels of cytokines including IL-1?, IL-9, MIP-2, and TNF-? in murine models, thereby demonstrating immunostimulatory activity with potential relevance to immune modulation research.

• Smiles:

  O=C (N1CC=C (C=2C=CC=CC2) CC1) C (NS (=O) (=O) C=3C=C (C=CC3C) C4=NOC (=N4) C5CC5) C

• Molecular Formula:

  C26H28N4O4S

• Molecular Weight:

  492.59

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1219395-86-4