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VU0364572 (TFA)

CAT: 0804-HY-113616A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113616A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU0364572 TFA is an orally active and selective allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. VU0364572 TFA has neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer’s Disease. VU0364572 TFA is CNS penetrant[1][3].
CAS Number
1240514-89-9
Product Name Alternative
WX-UK1; UKI-1C
UNSPSC
12352005
Target
MAChR; MARCKS
Type
Reference compound
Related Pathways
Cytoskeleton; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0364572-tfa.html
Purity
99.27
Solubility
DMSO : 55 mg/mL (ultrasonic)
Smiles
O=C(N1CCC(N2C[C@H](NC(C3=CC=CC=C3C)=O)CCC2)CC1)OCC.O=C(O)C(F)(F)F
Molecular Formula
C23H32F3N3O5
Molecular Weight
487.51
References & Citations
[1]Lebois EP, et al. Disease-Modifying Effects of M1 Muscarinic Acetylcholine Receptor Activation in an Alzheimer's Disease Mouse Model. ACS Chem Neurosci. 2017 Jun 21;8 (6) :1177-1187.|[2]Faruk MO, et al. Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning. J Neurochem. 2022 Feb;160 (3) :325-341.|[3]Lebois EP, et al. Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071. Bioorg Med Chem Lett. 2011 Nov 1;21 (21) :6451-5.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR1

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