CDK5-IN-3

• CAS Number:

  2639542-32-6

• UNSPSC Description:

  CDK5-IN-3 (compound 11) is a potent and selective CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD)[1].

• Target Antigen:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/cdk5-in-3.html

• Solubility:

  DMSO : 10 mg/mL (ultrasonic)

• Smiles:

  C[C@@](C1=CC=C2C(C=C(NC3=CC=CC=C3)N=C2)=N1)(O)C4CCN(C)CC4

• Molecular Weight:

  362.47

• References & Citations:

  [1]Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022 Feb 24;65(4):3575-3596.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported