CDK5-IN-3

CDK5-IN-3

• CAS Number: 2639542-32-6
• UNSPSC Description: CDK5-IN-3 (compound 11) is a potent and selective CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD)[1].
• Target Antigen: CDK
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/cdk5-in-3.html
• Solubility: DMSO : 10 mg/mL (ultrasonic)
• Smiles: C[C@@](C1=CC=C2C(C=C(NC3=CC=CC=C3)N=C2)=N1)(O)C4CCN(C)CC4
• Molecular Weight: 362.47
• References & Citations: [1]Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022 Feb 24;65(4):3575-3596.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported