CDK5-IN-4

CDK5-IN-4

• CAS Number: 1212711-91-5
• UNSPSC Description: CDK5-IN-4 (compound 4) is a potent multikinase type-II inhibitor targeting CDK5, with an IC50 of 9.8 μM. CDK5-IN-4 also inhibits GSK-3α, GSK-3β, CDK9, and CDK2, with IC50 values of 0.98, 4.00, 1.76, and 6.24 μM, respectively. CDK5-IN-4 can be used for glioblastoma research[1].
• Target Antigen: CDK; GSK-3
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;PI3K/Akt/mTOR;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cdk5-in-4.html
• Smiles: O=C(N[C@H]1CO[C@@H]2[C@H](CO[C@H]12)NC3=NC(C4=CC=CC(F)=C4)=CC=N3)NCC5=CC=CC=C5
• Molecular Weight: 449.48
• References & Citations: [1]Khan ZR, et al. Discovery of Potent Multikinase Type-II Inhibitors Targeting CDK5 in the DFG-out Inactive State with Promising Potential against Glioblastoma. J Med Chem. 2024 Apr 30.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported