CDK5-IN-2

• Description :

  CDK5-IN-2 (compound 15) is a highly selective CDK5 inhibitor with IC50s of 0.2 and 23 for CDK5/p25 and CDK2/CycA, respectively[1].

• UNSPSC :

  12352005

• Target :

  CDK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/cdk5-in-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC1=CC(C2=CC=CC(C#N)=C2)=CC=C1NC3=CC4=NC([C@](C)(O)C5CCN(C)CC5)=CC=C4C=N3

• Molecular Formula :

  C29H28FN5O

• Molecular Weight :

  481.56

• References & Citations :

  [1]Daniels MH, et al. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022;65 (4) :3575-3596.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDK2; CDK5

• CAS Number :

  [2639542-22-4]