CDK5-IN-2

CDK5-IN-2

• CAS Number: 2639542-22-4
• UNSPSC Description: CDK5-IN-2 (compound 15) is a highly selective CDK5 inhibitor with IC50s of 0.2 and 23 for CDK5/p25 and CDK2/CycA, respectively[1].
• Target Antigen: CDK
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-Kinase/protease
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/cdk5-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: FC1=CC(C2=CC=CC(C#N)=C2)=CC=C1NC3=CC4=NC([C@](C)(O)C5CCN(C)CC5)=CC=C4C=N3
• Molecular Weight: 481.56
• References & Citations: [1]Daniels MH, et al. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022;65(4):3575-3596.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported