CDK5-IN-2

CAT: 0804-HY-145693Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-145693Size:1 Each
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Description
CDK5-IN-2 (compound 15) is a highly selective CDK5 inhibitor with IC50s of 0.2 and 23 for CDK5/p25 and CDK2/CycA, respectively[1].
CAS Number
[2639542-22-4]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/cdk5-in-2.html
Solubility
10 mM in DMSO
Smiles
FC1=CC(C2=CC=CC(C#N)=C2)=CC=C1NC3=CC4=NC([C@](C)(O)C5CCN(C)CC5)=CC=C4C=N3
Molecular Formula
C29H28FN5O
Molecular Weight
481.56
References & Citations
[1]Daniels MH, et al. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022;65 (4) :3575-3596.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK5

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