CDK5-IN-2

• CAS Number:

  2639542-22-4

• UNSPSC Description:

  CDK5-IN-2 (compound 15) is a highly selective CDK5 inhibitor with IC50s of 0.2 and 23 for CDK5/p25 and CDK2/CycA, respectively[1].

• Target Antigen:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/cdk5-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=CC(C2=CC=CC(C#N)=C2)=CC=C1NC3=CC4=NC([C@](C)(O)C5CCN(C)CC5)=CC=C4C=N3

• Molecular Weight:

  481.56

• References & Citations:

  [1]Daniels MH, et al. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022;65(4):3575-3596.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported