4-Thiouridine 5′-triphosphate (tetralithium) | Gentaur

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4-Thiouridine 5′-triphosphate (tetralithium)

CAT:

804-HY-154840-02

Size:

1 mg

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4-Thiouridine 5′-triphosphate (tetralithium)

CAS Number: 20188-72-1
UNSPSC Description: 4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetralithium is a potent P2Y2 and P2Y4 receptor agonist, with EC50s of 35 and 350 nM for hP2Y2 and hP2Y4, respectively. 4-Thiouridine 5′-triphosphate tetralithium can be used in the study of crosslinking experiments, labeling of transcriptional complex[1][2].
Target Antigen: P2Y Receptor
Type: Reference compound
Related Pathways: GPCR/G Protein
Applications: COVID-19-immunoregulation
Field of Research: Inflammation/Immunology
Assay Protocol: https://www.medchemexpress.com/4-thiouridine-5-triphosphate-tetralithium.html
Solubility: 10 mM in DMSO
Smiles: O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=S)=O)O[C@@H]1COP(OP(OP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O
Molecular Weight: 523.94
References & Citations: [1]Jacobson KA, et, al. Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors. Biochem Pharmacol. 2006 Feb 14;71(4):540-9.|[2]Bartholomew B, et, al. RNA contacts subunits IIo and IIc in HeLa RNA polymerase II transcription complexes. J Biol Chem. 1986 Oct 25;261(30):14226-31.
Shipping Conditions: Room Temperature
Clinical Information: No Development Reported

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